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Peptide record

TPDB91526

peptide 1 Antibacterial Antiviral Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB91526
peptide 1
Antibacterial Antiviral Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0 CellPPD-MOD CPPsite3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antiviral, and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, AI4AVP, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with 5-Thio-2-Nitrobenzoic Acid-Disulfide (Tnb)
Sequence
RRRRRRRRRR-NH2
Physicochemical Analysis
C60H122N40O11
ANDCEQGHILKMFPSTWYV
R
1579.89
13.35
10
0
0
+10
8.10
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C60H122N40O11
1579.89
13.35
+10
8.10
-4.500
Amidation
L
Linear
Conjugated with 5-Thio-2-Nitrobenzoic Acid-Disulfide (Tnb)
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa And Hek293T

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Protein congugate I (NLS-mCherry-R10),Protein congugate II(NLS-mCherry-SS-R10) ,Protein congugate III (NLS-mCherry-SS-cR10)
Cytosol And Nucleolar
Coadministration of I (5 μM) with CPP-additives 1 or 2 (5 μM) in HeLa cells for one h resulted in nucleolar signals with more in 2.
Endocytosis
In vitro
CCCCTTTHHHHHHHTCC
Additional Detail Fields 1 fields
CCCCTTTHHHHHHHTCC