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Peptide record

TPDB91522

CyLoP-1 Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB91522
CyLoP-1
Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CAFPdb dbAMP CellPPD CellPPD-MOD CPPsite3.0 ToxinPred 3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
CRWRWKCCKK
Physicochemical Analysis
C61H97N21O11S3
ANDEQGHILMFPSTYV
CK
1396.76
10.32
5
0
2
+5
0.17
-1.500
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
11125
796.49
3
Residue Composition
number
0
A
2
R
0
N
0
D
3
C
0
E
0
Q
0
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
10
C61H97N21O11S3
1396.76
10.32
+5
0.17
-1.500
Free
L
Random coil Linear
Conjugated with FITC
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87Mg And T98G Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Random coil L
Protein derived
45% uptake efficiency in T98G cells
In vitro
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And Wheat Protoplasts

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
β-galactosidase
Cytoplasm
HeLa cells treated with β-galactsoidase-CyLoP-1 turned blue after incubation with buffer containing X-gal, while with β-galactosidase alone and Mut-CyLoP-1 did not exhibit a blue color.
Endocytosis and direct internalization
In vitro
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC