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Peptide record

TPDB91509

K9 Antibacterial Antifungal Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB91509
K9
Antibacterial Antifungal Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CAFPdb dbAMP CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Antifungal, and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Chemical: Calcium ions (Ca2+)
Sequence
KKKKKKKKK
Physicochemical Analysis
C54H110N18O10
ARNDCEQGHILMFPSTWYV
K
1171.58
11.41
9
0
0
+9
8.91
-3.900
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
9
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 9 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C54H110N18O10
1171.58
11.41
+9
8.91
-3.900
Free
Calcium ions (Ca2+)
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549, HeLa, MDA-MB-231, Llc, And Hek-293 Cell

Assay & Model

LLC allografts in Six-week-old wild-type male C57BL/6 mice
LLC allografts in Six-week-old wild-type male C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
plasmid DNA (pLUC and pAT2R)
In all cell lines examined, the transfection efficiency of the K9-pLUC-Ca2+ with 38 mM calcium chloride was significantly higher than those with PEI-pLUC , pLUC-Ca2+ (without K9) and the K9-pLUC-Ca2+ with 114 mM calcium chloride
In vitro and in vivo
CCSCCCCCC
Additional Detail Fields 1 fields
CCSCCCCCC