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Peptide record

TPDB91484

(Arg)9-GST-SH2 TrM Antibacterial Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB91484
(Arg)9-GST-SH2 TrM
Antibacterial Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CAFPdb dbAMP CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Chemical: TrM N-terminal: Gst
Sequence
RRRRRRRRR
Physicochemical Analysis
C54H110N36O10
ANDCEQGHILKMFPSTWYV
R
1423.70
13.30
9
0
0
+9
7.29
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C54H110N36O10
1423.70
13.30
+9
7.29
-4.500
Free
TrM
L
Cationic
Linear
Gst
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B16F10 Melanoma Cells, A375 (Braf Mutation)

Assay & Model

B16F10 cell Xenograft C57Bl/6 mice model (4–6 weeks old,18-22 g)
B16F10 cell Xenograft C57Bl/6 mice model (4–6 weeks old,18-22 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Synthetic
SH2 superbinder (a triple-mutant of the Src Homology 2 (SH2) domain)
Cytoplasm and nucleus
(Arg)9-GST-SH2 TrM showed highest green fluorescence signal than (Arg)9-GST or (Arg)9-GST SH2 Wt
PI3K/AKT, MAPK/ERK and JAK/STAT signaling pathways.
In vitro and in vivo