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Peptide record

TPDB91474

polyarginine (R9) Antibacterial Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB91474
polyarginine (R9)
Antibacterial Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CAFPdb dbAMP CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Chemical: FITC-labeled discoidal lipid nanoparticles (DLNPs)
Sequence
RRRRRRRRR
Physicochemical Analysis
C54H110N36O10
ANDCEQGHILKMFPSTWYV
R
1423.70
13.30
9
0
0
+9
7.29
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C54H110N36O10
1423.70
13.30
+9
7.29
-4.500
Free
FITC-labeled discoidal lipid nanoparticles (DLNPs)
L
Cationic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hacat And Nih3T3 Cells

Assay & Model

C57BL/6 wild-type female mice (6−8 weeks old)
C57BL/6 wild-type female mice (6−8 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Synthetic
APTstat3 peptide via (G)5S linker
Cytoplasmic And Nuclear Compartments
Intracellular fluorescence intensity gradually increased with increasing incubation time and APTstat3-9R concentration, reaching a maximum at 4 h. Also, [FITC-APTstat3-9R]- DLNPs exhibited a greater fluorescence signal in deeper layers of the skin in normal mouse ear skin treated compared with skin treated with FITC-APTstat3- 9R alone.
In vitro and in vivo