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Peptide record

TPDB91450

H3L-R9 Nona-arginine R8-p27kip1C R8-PAD R9-NH2 R9 Antibacterial Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB91450
H3L-R9 Nona-arginine R8-p27kip1C R8-PAD R9-NH2 R9
Antibacterial Antifungal Antiviral Blood-Brain Barrier Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CAFPdb dbAMP CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
RRRRRRRRR-NH2
Physicochemical Analysis
C54H110N36O10
ANDCEQGHILKMFPSTWYV
R
1423.70
13.30
9
0
0
+9
7.29
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C54H110N36O10
1423.70
13.30
+9
7.29
-4.500
Amidation
L
Cationic
Linear Cyclic Tetramer
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)O N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 9 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, T98G glioma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Peptide (cyclin-dependent kinase inhibitor)
Cytosol
In vitro
CCCCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, T98G glioma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Peptide [(Proapoptotic domain (PAD)]
Cytosol
In vitro
CCCCCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

HeLa cells

Source & Reference

CPPsite3.0
CPPsite3
US 2014/0140929 A1

Other

Natural residues Linear L Cationic
Synthetic
Nucleic acid (SCO)
Endocytosis
In vitro
CCCCCCCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Rat Primary Cortical Cultures

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
In vitro
CCCCCCCCC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
N-biotin-H3L-3xFLAG
Enhanced the cell penetration and endosome release of CPPs.
In vitro
CCCCCCCCC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293, A549

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
pDNA nanoparticles
Yielded high-gene expression values
In vitro
CCHHHHTTCC
Evidence 7 Activity

Activity

Cell-penetrating Peptides

Target

Giant Plasma Membrane Vesicles (Gpmv)Of Mb-231 And Rbl-2H3 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Fluor 633 (AF633) dye
In vitro
CCBTTBSSCC
Evidence 8 Activity

Activity

Cell-penetrating Peptides

Target

Huh-7 Or HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Cyclic L
Synthetic
5(6)-carboxyfluorescein (CF) and Cy5-labeled pDNA
Late Endosomes/Lysosomes
High penetration
In vitro
Evidence 9 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Br-3, Jimt-1, A431, Jurkat-Cells

Assay & Model

Athymic BALB/c nude mice xenografted A431tumors
Athymic BALB/c nude mice xenografted A431tumors

Source & Reference

CPPsite3.0
CPPsite3
EP2928502B1

Other

Natural residues Tetramer L Cationic
Synthetic
Anti-EGFR mAb matuzumab (Mat)
Endocytosis
In vitro and in vivo
CCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC CCHHHHTTCC CCBTTBSSCC CCCCCCC