TPDB

3D PDB MODEL

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TPDB ID TPDB91448

Peptide_Name

LfcinB (21-25)Pal LfcinB(21-25)Pal

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP pep-lab Peptipedia CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

RWQWRWQWR-NH2

FASTA

>TPDB91448|Antibacterial;Anticancer;Toxicity|length=9
RWQWRWQWR-NH2

Formula C72H94N24O12

Absent Amino Acids ANDCEGHILKMFPSTYV

Common Amino Acids W

Mass 1487.69

PI 12.70

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +3

Boman Index -3.81

Hydrophobicity -2.678

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 22000

Absorbance 280nm 1478.80

Polar Residues 2

number

0

A

3

R

0

N

0

D

0

C

0

E

2

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

4

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0

Length

9

Formula

C72H94N24O12

Mass

1487.69

PI

12.70

Net Charge

+3

Boman Index

-3.81

Hydrophobicity

-2.678

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Anticancer Antibacterial and Anticancer

Origin

LfcinB

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 86 µM

Detail Source Activity Anticancer

Activity Measurement 86 µM

Target

Cancer Type Colorectal Cancer

Cell Line CaCo-2

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 100 µM

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Colon Cancer

Cell Line HT-29

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 40 µM

Detail Source Activity Anticancer

Activity Measurement 40 µM

Target

Cancer Type Prostrate Cancer

Cell Line DU-145

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 72 µM

Detail Source Activity Anticancer

Activity Measurement 72 µM

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-468

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 103 µM

Detail Source Activity Anticancer

Activity Measurement 103 µM

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-231

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Evidence 6 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 81 µM

Detail Source Activity Anticancer

Activity Measurement 81 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023