Back to search

Peptide record

TPDB91440

linear (RW)4-Dox Antibacterial Anticancer Antifungal Antiviral Cell-penetrating Peptides Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB91440
linear (RW)4-Dox
Antibacterial Anticancer Antifungal Antiviral Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 SATPdb dbACP CAFPdb DRAMP dbAMP CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Chemical: Doxorubicin (Dox) which is anthracycline attached with linker to CPP [W(RW)4 ]
Sequence
RWRWRWRW
Physicochemical Analysis
C68H90N24O9
ANDCEQGHILKMFPSTYV
RW
1387.62
12.88
4
0
4
+4
-4.16
-2.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1585.45
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
8
C68H90N24O9
1387.62
12.88
+4
-4.16
-2.700
Free
Doxorubicin (Dox) which is anthracycline attached with linker to CPP [W(RW)4 ]
L
Linear
Free
Anticancer
Doxorubicin (Dox) is a well-known anthracycline which has been conjugated to a CPP
Evidence Records 4 records
Evidence 1 Activity

Activity

46-69% antiproliferative activity at 1 µM
Anticancer

Target

Leukemia Cancer
CCRF-CEM
Blood

Assay & Model

MTT/MTS assay
72 to 120-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

28-34% antiproliferative activity at 1 µM
Anticancer

Target

Ovarian Cancer
SK-OV-3
Ovary

Assay & Model

MTT/MTS assay
72 to 120-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013
Evidence 3 Activity

Activity

21-61% antiproliferative activity at 1 µM
Anticancer

Target

Colon Cancer
HCT-116
Colon

Assay & Model

MTT/MTS assay
72 to 120-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013
Evidence 4 Activity

Activity

60-74% antiproliferative activity at 1 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
72 to 120-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2013