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Peptide record

TPDB91407

STR-R8 Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB91407
STR-R8
Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Antiviral, Blood-Brain Barrier, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Chemical: NBD-DOPE labeled MITO-Porter N-terminal: Stearylation
Sequence
RRRRRRRR
Physicochemical Analysis
C48H98N32O9
ANDCEQGHILKMFPSTWYV
R
1267.52
13.25
8
0
0
+8
6.48
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C48H98N32O9
1267.52
13.25
+8
6.48
-4.500
Free
NBD-DOPE labeled MITO-Porter
L
Cationic
Linear
Stearylation
N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Mitochondrial RNA aptamers (CHOl-RP and CHOl-MRP) and the D-arm sequence (CHOl-D-arm)
Mitochondria
The cellular uptake of the R8-modified MITO-Porter was enhanced by modification with the RNA aptamer(independent on “aptamer type”), while the single modification of the RNA aptamer on R8-unmodified MITO-Porter had no effect on cellular uptake. however, RP/R8-modified MITO-Porter showed the highest Mitochondrial targeting rate.
Macropinocytosis and clathrin mediated endocytosis
In vitro
CCCCCCCCCCCCCSCCCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCCCSCCCCCCCCCCCCC