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Peptide record

TPDB91362

BBBpS_10 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB91362
BBBpS_10
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides Neuroactive peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP B3Pred BBPpredict CellPPD-MOD CPPsite3.0 ToxinPred 3.0
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
RPKPQQFFGLM-NH2
Physicochemical Analysis
C63H97N17O14S1
ANDCEHISTWYV
QFP
1348.63
11.49
2
0
4
+2
0.82
-0.700
35.45
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
2
Q
1
G
0
H
0
I
1
L
1
K
1
M
2
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 1 K: 1 M: 1 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C63H97N17O14S1
1348.63
11.49
+2
0.82
-0.700
Amidation
L
Hydrophobic
Linear
Conjugated with CF
N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hebc-5I, Hs68, HeLa, MDA-MB-231 And Hek-293 Cells

Assay & Model

7-weeks old CD1 female mice
7-weeks old CD1 female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
CF dye and Ga-radiolabed for in-vivo
Translocation =38.4 ± 5.3. Lowest uptakes (RFI<10.0).
In vitro and in vivo
CCSSSSCCCC
Additional Detail Fields 1 fields
CCSSSSCCCC