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Peptide record

TPDB91360

Temporin-Las Antibacterial Anticancer Toxicity Tumor-homing Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB91360
Temporin-Las
Antibacterial Anticancer Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF TumorHoPe2.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Toxicity, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
C-terminal: amide group (-NH2)
Sequence
LLRHVVKILSKYL
Physicochemical Analysis
C76H132N20O16
ANDCEQGMFPTW
L
1582.01
10.72
4
0
8
+3
0.53
0.808
194.62
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
94.18
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
4
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 4 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
13
C76H132N20O16
1582.01
10.72
+3
0.53
0.808
amide group (-NH2)
RGD
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Gastric cancer, Hepatocellular carcinoma, Colorectal cancer, Lung adenocarcinoma
integrin avb3

Source & Reference

TumorHoPe2.0
TumorHoPe2
Designed synthetic analogs of the α-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin αvβ3 homing domain
2012
Yuwen Diao et al. J Pept Sci. 2012 Jul 18(7):476-86.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
lung adenocarcinoma epithelial cell line(A549), human colorectal carcinomacell line(SW1116),humangastric carcinoma cell line (BGC-823), human epithelial carcinomacell line (Hela), humanhepatocellular liver carcinomacell line(HepG2), human hepato carcinoma cell line(SMMC-7721),human embryonic kidney cell line (HEK 293T), human liver cell line (HL-7702), bovine mammary epithelial cells(MECs),andperipheral blood mononuclear cell(PBMC)
Synthetic
Additional Detail Fields 1 fields
lung adenocarcinoma epithelial cell line(A549), human colorectal carcinomacell line(SW1116),humangastric carcinoma cell line (BGC-823), human epithelial carcinomacell line (Hela), humanhepatocellular liver carcinomacell line(HepG2), human hepato carcinoma cell line(SMMC-7721),human embryonic kidney cell line (HEK 293T), human liver cell line (HL-7702), bovine mammary epithelial cells(MECs),andperipheral blood mononuclear cell(PBMC)