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Peptide record

TPDB91355

tachyplesin I T1 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB91355
tachyplesin I T1
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AFP-GFuse Antifp Antifungipept CAFPdb dbAMP 3.0 AI4AVP AVPpred-BWR CellPPD-MOD CPPsite3.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
KWCFRVCYRGICYRRCR-NH2
Physicochemical Analysis
C99H154N34O20S4
ANDEQHLMPST
R
2268.77
10.10
6
0
6
+6
-1.01
-0.518
40.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8730
384.79
6
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
0
Q
1
G
0
H
1
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
17
C99H154N34O20S4
2268.77
10.10
+6
-1.01
-0.518
Amidation
L
Linear
Linear
Free
Host Defense Peptide
Horseshoe Crab
Evidence Records 8 records
Evidence 1 Activity

Activity

CC50
CC50 = 1.5 ± 0.1 µM
Anticancer
1.5

Target

Skin Cancer
MM96L
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 2 Activity

Activity

CC50
CC50 = 1.7 ± 0.2 µM
Anticancer
1.7

Target

Skin Cancer
HT-144
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2019
Evidence 3 Activity

Activity

CC50
CC50 = 2.5 ± 0.1 µM
Anticancer
2.5

Target

Skin Cancer
WM164
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2019
Evidence 4 Activity

Activity

CC50
CC50 = 8.0 ± 0.6 µM
Anticancer
8.0

Target

Skin Cancer
MDA-MB-435S
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2019
Evidence 5 Activity

Activity

CC50
CC50 = 1.7 ± 0.1 µM
Anticancer
1.7

Target

Leukemia Cancer
K-562
Blood

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2019
Evidence 6 Activity

Activity

CC50
CC50 = 16.0 ± 2.0 µM
Anticancer
16.0

Target

Breast Cancer
MCF-7
Breast

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2019
Evidence 7 Activity

Activity

CC50
CC50 = 13.1 ± 1.2 µM
Anticancer
13.1

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

Resazurin dye assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2019
Evidence 8 Activity

Activity

Cell-penetrating Peptides

Target

Bmm Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Protein derived
Alexa Fluor 488-conjugated
Cytoplasm
Internalized into~100% BMMs at 1 μM
In vitro