TPDB

3D PDB MODEL

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TPDB ID TPDB91344

Peptide_Name

mPTD

Activity

Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF CAFPdb dbAMP BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.

Modification

Chemical: Micelle

Sequence

RKKRRQRRR

FASTA

>TPDB91344|Antibacterial;Anticancer;Antifungal;Blood-Brain Barrier;Cell-penetrating Peptides;Toxicity;Tumor-homing Peptides|length=9
RKKRRQRRR

Formula C53H106N30O11

Absent Amino Acids ANDCEGHILMFPSTWYV

Common Amino Acids R

Mass 1339.62

PI 13.10

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +8

Boman Index 7.42

Hydrophobicity -4.256

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

6

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

2

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

9

Formula

C53H106N30O11

Mass

1339.62

PI

13.10

Net Charge

+8

Boman Index

7.42

Hydrophobicity

-4.256

C_terminal_Modification

Free

Chemical_Modification

Micelle

Chirality

L

Ionic_State

Cationic

Linearity

Linear

N_terminal_Modification

Free

SMILES

N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Lx2 Cells Liver And Tissue Of Mice

Assay & Model

In Vitro Model 4-week-old C57BL/6 males

In Vivo Model 4-week-old C57BL/6 males

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L Cationic

Source of Peptide Protein derived

Cargo Type Bone morphogenetic protein-7 (BMP-7)

Subcellular Localization Cytosol (Golgi Apparatus)

Uptake Mechanism Endocytosis

In Vitro or In Vivo In-vitro, in-vivo and ex vivo

DSSP Secondary Structure CCCCSSCCSCC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line 293A Cells

Assay & Model

In Vitro Model Six-week old C57BL/6 mice (mouse UUO model) and female 12-week-age Yorkshire pig

In Vivo Model Six-week old C57BL/6 mice (mouse UUO model) and female 12-week-age Yorkshire pig

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Protein derived

Cargo Type Bone morphogenetic protein‐7 (BMP‐7)

Subcellular Localization Cytosol And Golgi Apparatus

Uptake Efficiency Time-dependent internalization

Uptake Mechanism Endosomal pathway

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCTTSSCCCCC

DSSP_Secondary_Structure

CCCCSSCCSCC CCTTSSCCCCC