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Peptide record

TPDB91340

TAT-GFP TAT-LL37-VHHm3F TAT-VHHm3F Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB91340
TAT-GFP TAT-LL37-VHHm3F TAT-VHHm3F
Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF CAFPdb dbAMP BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Chemical: DiR labelled EVs
Sequence
RKKRRQRRR
Physicochemical Analysis
C53H106N30O11
ANDCEGHILMFPSTWYV
R
1339.62
13.10
8
0
0
+8
7.42
-4.256
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C53H106N30O11
1339.62
13.10
+8
7.42
-4.256
Free
DiR labelled EVs
L
Cationic
Linear
Free
N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human Caco-2 Cells And Murine L929 Cells

Assay & Model

Adult C57BL/6 normal mice
Adult C57BL/6 normal mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Green fluorescent protein (GFP)
TAT-GFP dose of 15 mg/kg in mice resulted in GFP primarily accumulating in colon after 4 h
In vitro and in vivo
CCCSSHHHHHHHHHHHHHHHHHHHSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Human Caco-2 Cells And Murine L929 Cells

Assay & Model

Adult C57BL/6 normal mice
Adult C57BL/6 normal mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Anti‐tumour necrosis factor‐α (TNF‐α) nanobody (VHHm3F)
76.1% of EV were FITC-positive after incubation of FAM-labelled TAT-VHHm3F
In vitro and in vivo
CCGGGTSCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Human Caco-2 Cells

Assay & Model

Adult C57BL/6 normal mice
Adult C57BL/6 normal mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
VHH and an antimicrobial peptide LL37
87% of EV were FITC-positive when FAM-labelled TAT-LL37-VHHm3F was incubated with EV
In vitro and in vivo
CCGGGTSCC
Additional Detail Fields 1 fields
CCCSSHHHHHHHHHHHHHHHHHHHSSCC CCGGGTSCC