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Peptide record

TPDB91332

Br-TAT Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB91332
Br-TAT
Antibacterial Anticancer Antifungal Blood-Brain Barrier Cell-penetrating Peptides Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF CAFPdb dbAMP BBPpredict CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Bromoacetic Acid
Sequence
RKKRRQRRR-NH2
Physicochemical Analysis
C53H106N30O11
ANDCEGHILMFPSTWYV
R
1339.62
13.10
8
0
0
+8
7.42
-4.256
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C53H106N30O11
1339.62
13.10
+8
7.42
-4.256
Amidation
L
Cationic
Linear
Bromoacetic Acid
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Assay & Model

Fibrosarcoma bearing Swiss mice (4–6 weeks age, 20–25 g weight)
Fibrosarcoma bearing Swiss mice (4–6 weeks age, 20–25 g weight)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Porphyrin derivative at N terminus and radiolabeled with 68GaCl3
Cytosol
Higher cell internalization for UTriCOOHPhO–TAT compared to UTriCOOHPhOH
In vitro and in vivo
CCCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCCC