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Peptide record

TPDB91322

Tat2 Tat2-Nat Antibacterial Antifungal Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB91322
Tat2 Tat2-Nat
Antibacterial Antifungal Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP CPPsite3.0 MLCPP 2.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
RKKRRQRRRRKKRRQRRR
Physicochemical Analysis
C106H210N60O21
ANDCEGHILMFPSTWYV
R
2661.22
13.44
16
0
0
+16
14.84
-4.256
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
12
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C106H210N60O21
2661.22
13.44
+16
14.84
-4.256
Free
L
Cationic
Dimer Linear
Conjugated with FITC
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87Mg And T98G Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Dimer L Cationic
Synthetic
70% uptake efficiency in T98G cells
In vitro
CCCGGGGGTCCCCTTSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And Hce Cells Hyphae Of F. Solani

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
FITC labelled
Cytoplasm and nucleus
Tat2 displayed 1.5-fold higher uptake in cells as compared to Tat2-Nat
Clathrin mediated endocytosis
In vitro
CCHHHHHHHHTTC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And Hce Cells Hyphae Of F. Solani

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Natamycin at C terminus
Cytoplasm and nucleus
Tat2-Nat internalize efficiently inside the cells
More than one endocytosis pathways
In vitro
CCSSCGGGGGTCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Fusarium Solani

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L
Protein derived
FITC dye
In vitro
Additional Detail Fields 1 fields
CCCGGGGGTCCCCTTSSCC CCHHHHHHHHTTC CCSSCGGGGGTCC