TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB91317

Peptide_Name

Crabrolin

Activity

Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 iACP-DRLF Antifungipept APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

FLPLILRKIVTAL-NH2

FASTA

>TPDB91317|Antibacterial;Anticancer;Antifungal;Antiparasitic;Cell-penetrating Peptides;Hemolysis;Toxicity|length=13
FLPLILRKIVTAL-NH2

Formula C74H129N17O15

Absent Amino Acids NDCEQGHMSWY

Common Amino Acids L

Mass 1496.94

PI 11.49

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +2

Boman Index -1.70

Hydrophobicity 1.715

Aliphatic Index 210.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

2

I

4

L

1

K

0

M

1

F

1

P

0

S

1

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 1 M: 0 F: 1 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

13

Formula

C74H129N17O15

Mass

1496.94

PI

11.49

Net Charge

+2

Boman Index

-1.70

Hydrophobicity

1.715

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

European hornet (Vespa crabro)

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 27.71 µM

Detail Source Activity Anticancer

Activity Measurement 27.71 µM

Target

Cancer Type Lung Cancer

Cell Line H-838

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 32.13 µM

Detail Source Activity Anticancer

Activity Measurement 32.13 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 20.13 µM

Detail Source Activity Anticancer

Activity Measurement 20.13 µM

Target

Cancer Type Brain Tumor

Cell Line U-251-MG

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 8.539 µM

Detail Source Activity Anticancer

Activity Measurement 8.539 µM

Target

Cancer Type Colon Cancer

Cell Line HCT-116

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 26.49 µM

Detail Source Activity Anticancer

Activity Measurement 26.49 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2023