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Peptide record

TPDB91316

VIP Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB91316
VIP
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides Neuroactive peptides
AntiBP3 dbAMP Peptipedia AFP-GFuse Antifungipept CAFPdb i2APP AI4AVP B3Pred BBPpredict CPPsite3.0 ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2
Physicochemical Analysis
C147H237N43O43S1
CEGPW
NLK
3326.82
10.22
6
2
12
+3
4.96
-0.639
83.57
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
2980
89.57
10
Residue Composition
number
2
A
2
R
3
N
2
D
0
C
0
E
1
Q
0
G
1
H
1
I
3
L
3
K
1
M
1
F
0
P
2
S
2
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 3 D: 2 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 3 K: 3 M: 1 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 2 V: 2
Chemical Descriptors
28
C147H237N43O43S1
3326.82
10.22
+3
4.96
-0.639
Amidation
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
FITC labelled
Levels of internalization of VIP were around 50% of that observed for the TAT (48–60) peptide
In vitro
CCTTTCTHHHHHHHTTCC
Additional Detail Fields 1 fields
CCTTTCTHHHHHHHTTCC