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Peptide record

TPDB91312

Cyclotide mela-6 Antibacterial Anticancer Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB91312
Cyclotide mela-6
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
C-terminal: Cyclized N-terminal: Cyclized
Sequence
GLPTCGETCFKGKCYTPGCSCSYPICKKD
Physicochemical Analysis
C131H205N33O41S6
ARNQHMWV
C
3090.63
8.01
4
2
5
+2
3.96
-0.317
26.90
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
108.55
13
Residue Composition
number
0
A
0
R
0
N
1
D
6
C
1
E
0
Q
4
G
0
H
1
I
1
L
4
K
0
M
1
F
3
P
2
S
3
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 6 E: 1 Q: 0 G: 4 H: 0 I: 1 L: 1 K: 4 M: 0 F: 1 P: 3 S: 2 T: 3 W: 0 Y: 2 V: 0
Chemical Descriptors
29
C131H205N33O41S6
3090.63
8.01
+2
3.96
-0.317
Cyclized
L
Cyclic
Cyclized
Antibacterial and Anticancer
Melicytus latifolius
Evidence Records 2 records
Evidence 1 Activity

Activity

CC50
CC50 = 1.58 ±0.48 µM
Anticancer
1.58

Target

Skin Cancer
MM96L
Skin

Assay & Model

Resazurin dye assay
Not Available

Source & Reference

CancerPPD 2.0
CancerPPD2
2015

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

CC50
CC50 = 11.42 ±1.00 µM
Anticancer
11.42

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

Resazurin dye assay
Not Available

Source & Reference

CancerPPD 2.0
CancerPPD2
2015