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Peptide record

TPDB91306

OT20 Antibacterial Cell-penetrating Peptides Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB91306
OT20
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with 5(6)-Carboxyfluorescein (CF)
Sequence
TKPKGTKPKGTKPKGTKPKG-NH2
Physicochemical Analysis
C92H166N28O25
ARNDCEQHILMFSWYV
K
2064.50
11.36
8
0
0
+8
10.32
-2.100
0.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
0
I
0
L
8
K
0
M
0
F
4
P
0
S
4
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 0 K: 8 M: 0 F: 0 P: 4 S: 0 T: 4 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C92H166N28O25
2064.50
11.36
+8
10.32
-2.100
Amidation
L
Cationic and amphiphilic
Linear
Conjugated with 5(6)-Carboxyfluorescein (CF)
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Monomac-6, Ebc-1 And Calu-1 Cells Mycobacterium Tuberculosis H37Rv

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphiphilic
CF dye and Isoniazid (INH) at N terminus
In vitro
CCSCCCSSSSCCCCCCCCCC
Additional Detail Fields 1 fields
CCSCCCSSSSCCCCCCCCCC