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Peptide record

TPDB91294

Citropin 1.1 Citropin1.1 Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Neuropeptide Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB91294
Citropin 1.1 Citropin1.1
Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Neuropeptide Toxicity
Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides Neuroactive peptides
Peptipedia AntiBP3 dbAMP DRAMP ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, AntiBP3, dbAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
GLFDVIKKVASVIGGL-NH2
Physicochemical Analysis
C76H130N18O20
RNCEQHMPTWY
GV
1615.98
9.88
2
1
9
+1
0.54
1.281
158.12
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
3
G
0
H
2
I
2
L
2
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 2 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
16
C76H130N18O20
1615.98
9.88
+1
0.54
1.281
Amidation
L
Linear
Free
Antibacterial Antimicrobial and Anticancer Antimicrobial
Australian blue mountains tree frog, Litoria citropa Amphibian skin secretions
Evidence Records 12 records
Evidence 1 Activity

Activity

60% Cytotoxicity at 0.5 µg/ml
Anticancer

Target

Lymphoma Cancer
U-937
Blood

Assay & Model

MTT/MTS assay
6-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2009

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

60% Cytotoxicity at 0.5 µg/ml
Anticancer

Target

Lymphoma Cancer
U-937
Blood

Assay & Model

MTT/MTS assay
6-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2009
Evidence 3 Activity

Activity

IC50
IC50= 5 M
Anticancer
5

Target

Leukemia Cancer
Leukemia tumor cellline
Blood

Assay & Model

Sulforhodamine B assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003
Evidence 4 Activity

Activity

IC50
IC50= 5 M
Anticancer
5

Target

Lung Cancer
Lung tumor cellline
Lung

Assay & Model

Sulforhodamine B assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003
Evidence 5 Activity

Activity

IC50
IC50= 5 M
Anticancer
5

Target

Colon Cancer
Colon tumor cellline
Colon

Assay & Model

Sulforhodamine B assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003
Evidence 6 Activity

Activity

IC50
IC50= 5 M
Anticancer
5

Target

Brain Tumor
Brain tumor cellline
Brain

Assay & Model

Sulforhodamine B assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003
Evidence 7 Activity

Activity

IC50
IC50= 5 M
Anticancer
5

Target

Skin Cancer
Skin tumor cellline
Skin

Assay & Model

Sulforhodamine B assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003
Evidence 8 Activity

Activity

IC50
IC50= 5 M
Anticancer
5

Target

Ovarian Cancer
Ovary tumor cellline
Ovary

Assay & Model

Sulforhodamine B assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003
Evidence 9 Activity

Activity

IC50
IC50= 5 M
Anticancer
5

Target

Liver Cancer
Liver tumor celline
Liver

Assay & Model

Sulforhodamine B assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003
Evidence 10 Activity

Activity

IC50
IC50= 5 M
Anticancer
5

Target

Prostate Cancer
Prostate tumor cellline
Prostate

Assay & Model

Sulforhodamine B assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003
Evidence 11 Activity

Activity

IC50
IC50= 5 M
Anticancer
5

Target

Breast Cancer
Breast tumor cellline
Breast

Assay & Model

Sulforhodamine B assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003
Evidence 12 Activity

Activity

IC50
IC50 =40 µg/ml
Anticancer
40 µg/mL

Target

Lymphoma Cancer
U-938
Blood

Assay & Model

MTT/MTS assay
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011