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Peptide record

TPDB91284

2BP100 Antibacterial Cell-penetrating Peptides Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB91284
2BP100
Antibacterial Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Conjugated with TAMRA Chemical: Lys side chain amine at the C-terminus
Sequence
KKLFKKILKYLKKLFKKILKYL
Physicochemical Analysis
C144H246N32O25
ARNDCEQGHMPSTWV
K
2825.74
10.93
10
0
12
+10
1.78
-0.191
141.82
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
2980
105.46
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
6
L
10
K
0
M
2
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 6 K: 10 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
22
C144H246N32O25
2825.74
10.93
+10
1.78
-0.191
Conjugated with TAMRA
Lys side chain amine at the C-terminus
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

By-2 Cells Leaves Of Nicotiana Benthamiana, Arabidopsis Thaliana, Tomato (Solanum Lycopersicum), Poplar (Hybrid Aspen Populus Tremula×Tremuloides Line T89), And Rice (Oryza Sativa).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
TAMRA dye
BP100 (Peptide No. 1), dhvar5 (Peptide No. 26), HPV33L2-445/467 (Peptide No. 27), Crot(27 39) (Peptide No.37), and CyLoP-1 (Peptide No. 40). have medium efficiency in BY-2 cells.
In vitro
CTTHHHHHHHHHHHHTTTTTTC
Additional Detail Fields 1 fields
CTTHHHHHHHHHHHHTTTTTTC