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Peptide record

TPDB91260

SP15 Antibacterial Cell-penetrating Peptides Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB91260
SP15
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CPPsite3.0
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
RWIRWVWRKKLR-NH2
Physicochemical Analysis
C86H135N29O13
ANDCEQGHMFPSTY
R
1783.20
12.88
6
0
6
+6
-1.13
-1.333
89.17
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
925.30
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
2
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
12
C86H135N29O13
1783.20
12.88
+6
-1.13
-1.333
Amidation
L
Cationic
Linear
Free
NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Escherichia Coli Atcc 25,922 Bacterial Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
FITC -conjugated
Cytoplasm
At 100 μg/mL, make significant changes in the membrane structure and becomes permeable for FITC
In vitro
CHHHHHHHHTCC
Additional Detail Fields 1 fields
CHHHHHHHHTCC