TPDB

3D PDB MODEL

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TPDB ID TPDB91254

Peptide_Name

CREKA

Activity

Antibacterial Anticancer Cell-penetrating Peptides Toxicity Tumor-homing Peptides

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 Peptipedia CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CellPPD-MOD, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

CREKAKKLFKKILKKL-NH2

FASTA

>TPDB91254|Antibacterial;Anticancer;Cell-penetrating Peptides;Toxicity;Tumor-homing Peptides|length=16
CREKAKKLFKKILKKL-NH2

Formula C92H168N26O19S1

Absent Amino Acids NDQGHMPSTWYV

Common Amino Acids K

Mass 1974.57

PI 10.91

Basic Residues 8

Acidic Residues 1

Hydrophobic Residues 6

Net Charge +7

Boman Index 6.23

Hydrophobicity -0.769

Aliphatic Index 103.75

Half Life

Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

1

R

0

N

0

D

1

C

1

E

0

Q

0

G

0

H

1

I

3

L

7

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 1 E: 1 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 7 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

16

Formula

C92H168N26O19S1

Mass

1974.57

PI

10.91

Net Charge

+7

Boman Index

6.23

Hydrophobicity

-0.769

C_terminal_Modification

Amide

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor vessel

Homing or Targeting Homing

Target Tumor Breast cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties

Year 2014

Reference

Marta Soler et al. Org Biomol Chem. 2014 Mar 14, 12, 1652-1663

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo breast adenocarcinoma MCF-7, pancreas adenocarcinoma CAPAN-1, mouse embryonic fibroblast 3T3 cell line

Source Type Phage display library

Phage Display Library CECMEL11 peptide library

Conjugate Payload BP327 (KKLFKKILKKL)

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor vessel

Homing or Targeting Homing

Target Tumor Breast cancer

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties

Year 2014

Reference

Marta Soler et al. Org Biomol Chem. 2014 Mar 14, 12, 1652-1663

Other

InVitro ExVivo breast adenocarcinoma MCF-7, pancreas adenocarcinoma CAPAN-1, mouse embryonic fibroblast 3T3 cell line

Source Type Phage display library

Phage Display Library CECMEL11 peptide library

Conjugate Payload BP16 (KKLFKKILKKL)

Conjugate_Payload

BP327 (KKLFKKILKKL) BP16 (KKLFKKILKKL)

InVitro_ExVivo

breast adenocarcinoma MCF-7, pancreas adenocarcinoma CAPAN-1, mouse embryonic fibroblast 3T3 cell line

Phage_Display_Library

CECMEL11 peptide library