TPDB

3D PDB MODEL

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TPDB ID TPDB91247

Peptide_Name

cyclic dipeptide - 7b

Activity

Antibacterial Anticancer Antifungal Antihypertensive Antioxidant Toxicity iDPPIV

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides

Database_Source

Peptipedia CancerPPD 2.0 CAFPdb dbAMP AHTPDB AHTpin AODB Multi-AOP iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, CAFPdb, and other sources, with an available 3D structural model.

Modification

C-terminal: Cyclized Chemical: L-7dimethylallyl at Trp N-terminal: Cyclized

Sequence

WP

FASTA

>TPDB91247|Antibacterial;Anticancer;Antifungal;Antihypertensive;Antioxidant;Toxicity;iDPPIV|length=2
WP

Formula C16H19N3O3

Absent Amino Acids ARNDCEQGHILKMFSTYV

Common Amino Acids PW

Mass 301.35

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index -1.40

Hydrophobicity -1.250

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 1825.15

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

2

Formula

C16H19N3O3

Mass

301.35

PI

6.02

Net Charge

-0

Boman Index

-1.40

Hydrophobicity

-1.250

C_terminal_Modification

Cyclized

Chemical_Modification

L-7dimethylallyl at Trp

Chirality

L

Linear_or_Cyclic

Cyclic

N_terminal_Modification

Cyclized

Nature

Anticancer

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 92.2 µM

Detail Source Activity Anticancer

Activity Measurement 92.2 µM

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 82.3 µM

Detail Source Activity Anticancer

Activity Measurement 82.3 µM

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 97.1 µM

Detail Source Activity Anticancer

Activity Measurement 97.1 µM

Target

Cancer Type Lung Cancer

Cell Line A-549

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 82.5 µM

Detail Source Activity Anticancer

Activity Measurement 82.5 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 72-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020