TPDB

3D PDB MODEL

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TPDB ID TPDB91241

Peptide_Name

maximin1

Activity

Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 AI4AVP AVPpred-BWR DRAVP 2.0 APD_complete APD_hemolytic Hemolytic2

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

GIGTKILGGVKTALKGALKELASTYAN-NH2

FASTA

>TPDB91241|Antibacterial;Anticancer;Antifungal;Antioxidant;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=27
GIGTKILGGVKTALKGALKELASTYAN-NH2

Formula C120H208N32O36

Absent Amino Acids RDCQHMFPW

Common Amino Acids G

Mass 2675.16

PI 10.31

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +3

Boman Index 2.59

Hydrophobicity 0.252

Aliphatic Index 112.22

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 55.70

Polar Residues 6

number

4

A

0

R

1

N

0

D

0

C

1

E

0

Q

5

G

0

H

2

I

4

L

4

K

0

M

0

F

0

P

1

S

3

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 4 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 5 H: 0 I: 2 L: 4 K: 4 M: 0 F: 0 P: 0 S: 1 T: 3 W: 0 Y: 1 V: 1

Length

27

Formula

C120H208N32O36

Mass

2675.16

PI

10.31

Net Charge

+3

Boman Index

2.59

Hydrophobicity

0.252

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Bombina maxima

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=15.3 µg/ml

Detail Source Activity Anticancer

Activity Measurement 15.3 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line C8166

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=24.3 µg/ml

Detail Source Activity Anticancer

Activity Measurement 24.3 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line MOLT-4

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=20.5 µg/ml

Detail Source Activity Anticancer

Activity Measurement 20.5 µg/mL

Target

Cancer Type Bladder Cancer

Cell Line BIU-87

Tissue Affected Bladder

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =35.4 µg/ml

Detail Source Activity Anticancer

Activity Measurement 35.4 µg/mL

Target

Cancer Type Bladder Cancer

Cell Line T-24

Tissue Affected Bladder

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001