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Peptide record

TPDB87414

RGD-GNNNQNY-CPT Selfassembly modified_plain modified
10 amino acids
Basic Information
TPDB87414
RGD-GNNNQNY-CPT
Selfassembly
Self-assembling and biomaterial peptides
ScienceDirect
modified_plain
Yes
A 10-aa modified selfassembly peptide sequence curated from ScienceDirect, without an available 3D structural model.
Modified, details unspecified
Sequence
RGD-GNNNQNY-CPT
Physicochemical Analysis
C56H85N21O23S1
AEHILKMFSWV
N
1452.48
6.09
1
1
1
-0
3.73
-1.827
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
102.58
8
Residue Composition
number
0
A
1
R
4
N
1
D
1
C
0
E
1
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 4 D: 1 C: 1 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
10
C56H85N21O23S1
1452.48
6.09
-0
3.73
-1.827
Self-Assembly Information 1 records
Record 1 ScienceDirect

Source

10.1016/j.biomaterials.2021.121139
Targeted in situ self-assembly augments peptide drug conjugate cell-entry efficiency

Self-Assembly

Nanostructure formation
Self-assembled peptide-drug conjugate nanostructure
Tumor/cell-targeted in situ assembly
Selfassembly; Nanostructure=Self-assembled peptide-drug conjugate nanostructure; Trigger=Tumor/cell-targeted in situ assembly
Self-assembly characterization cell-entry and animal therapeutic-window assays
Cancer therapy
drug carrier active peptide
ScienceDirect
Selfassembly
Evidence Records 1 records
Evidence 1 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Self-assembled peptide-drug conjugate nanostructure Trigger=Tumor/cell-targeted in situ assembly
Self-assembled peptide-drug conjugate nanostructure

Source & Reference

NA
ScienceDirect
10.1016/j.biomaterials.2021.121139

Other

Camptothecin payload conjugated RGD targeting motif
Cancer therapy
drug carrier active peptide
Tumor/cell-targeted in situ assembly
Self-assembly characterization cell-entry and animal therapeutic-window assays
Targeted in situ self-assembly augments peptide drug conjugate cell-entry efficiency
Assembly motif is GNNNQNY payload is CPT.
Additional Detail Fields 6 fields
Tumor/cell-targeted in situ assembly
Camptothecin payload conjugated RGD targeting motif
Assembly motif is GNNNQNY payload is CPT.
Targeted in situ self-assembly augments peptide drug conjugate cell-entry efficiency
Cancer therapy
drug carrier active peptide