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Peptide record

TPDB87410

MMP2-sensitive RGDS PA Selfassembly modified_plain modified
12 amino acids
Basic Information
TPDB87410
MMP2-sensitive RGDS PA
Selfassembly
Self-assembling and biomaterial peptides
PMC
modified_plain
Yes
A 12-aa modified selfassembly peptide sequence curated from PMC, without an available 3D structural model.
Modified, details unspecified
Sequence
palmitoyl-GTAGLIGQRGDS
Physicochemical Analysis
C89H148N24O28S1
NCEHKFWV
G
2034.36
6.71
1
1
9
-0
-0.29
0.350
97.73
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
73.24
5
Residue Composition
number
2
A
1
R
0
N
1
D
0
C
0
E
1
Q
4
G
0
H
2
I
3
L
0
K
1
M
0
F
1
P
1
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 4 H: 0 I: 2 L: 3 K: 0 M: 1 F: 0 P: 1 S: 1 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C89H148N24O28S1
2034.36
6.71
-0
-0.29
0.350
Self-Assembly Information 1 records
Record 1 PMC

Source

19281184
10.1021/mp900009n
Self-Assembling Peptide Amphiphile-Based Nanofiber Gel for Bioresponsive Cisplatin Delivery

Self-Assembly

Nanostructure formation
Cross-linked nanofiber gel
Mixing with cisplatin at 37 C enzyme-responsive degradation by MMP-2
Selfassembly; Nanostructure=Cross-linked nanofiber gel; Trigger=Mixing with cisplatin at 37 C; enzyme-responsive degradation by MMP-2
Rheology TEM MMP-2-triggered release
Targeted anticancer drug delivery
drug carrier
PMC
Selfassembly
Evidence Records 1 records
Evidence 1 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Cross-linked nanofiber gel Trigger=Mixing with cisplatin at 37 C enzyme-responsive degradation by MMP-2
Cross-linked nanofiber gel

Source & Reference

NA
PMC
10.1021/mp900009n

Other

Palmitoyl lipid tail MMP-2-sensitive peptide RGDS motif
Targeted anticancer drug delivery
drug carrier
Mixing with cisplatin at 37 C enzyme-responsive degradation by MMP-2
Rheology TEM MMP-2-triggered release
19281184
Self-Assembling Peptide Amphiphile-Based Nanofiber Gel for Bioresponsive Cisplatin Delivery
Drug is cisplatin peptide amphiphile itself is carrier.
Additional Detail Fields 7 fields
Mixing with cisplatin at 37 C enzyme-responsive degradation by MMP-2
Palmitoyl lipid tail MMP-2-sensitive peptide RGDS motif
Drug is cisplatin peptide amphiphile itself is carrier.
19281184
Self-Assembling Peptide Amphiphile-Based Nanofiber Gel for Bioresponsive Cisplatin Delivery
Targeted anticancer drug delivery
drug carrier