Back to search

Peptide record

TPDB87403

P11-4 P11-4-enamel Selfassembly modified_plain modified
11 amino acids
Basic Information
TPDB87403
P11-4 P11-4-enamel
Selfassembly
Self-assembling and biomaterial peptides
PubMed Peptipedia MedChemExpress
modified_plain
Yes
A 11-aa modified selfassembly peptide sequence curated from PubMed, Peptipedia, and MedChemExpress, without an available 3D structural model.
C-terminal: Amidation
Sequence
Ac-QQRFEWEFEQQ-NH2
Physicochemical Analysis
C86H118N26O27S1
DGILKMPSTYV
Q
1980.10
4.53
2
3
4
-2
6.05
-1.483
5.56
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
277.76
6
Residue Composition
number
1
A
1
R
1
N
0
D
1
C
3
E
4
Q
0
G
1
H
0
I
0
L
0
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 1 E: 3 Q: 4 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
11
C86H118N26O27S1
1980.10
4.53
-2
6.05
-1.483
Self-Assembly Information 3 records
Record 1 PubMed

Source

33026894
10.1080/00016357.2020.1825799
Self-assembling peptide P11-4 in remineralization of enamel caries - a systematic review of in-vitro studies

Self-Assembly

Nanostructure formation
Beta-sheet scaffold/hydrogel-like matrix
Low pH in caries lesion
Selfassembly; Nanostructure=Beta-sheet scaffold/hydrogel-like matrix; Trigger=Low pH in caries lesion
Systematic review AFM/SEM in erosion studies clinical studies
Early enamel caries enamel remineralization
biomimetic mineralization scaffold
PubMed
Selfassembly
Record 2 PubMed

Source

37245138
10.1016/j.adaj.2023.03.014
Systematic review and meta-analysis on the effect of self-assembling peptide P11-4 on arrest cavitation and progression of initial caries lesions

Self-Assembly

Nanostructure formation
Self-assembled enamel matrix-like scaffold
Low pH in caries lesion
Selfassembly; Nanostructure=Self-assembled enamel matrix-like scaffold; Trigger=Low pH in caries lesion
Clinical meta-analysis evidence
Initial caries lesion arrest and regression
biomimetic mineralization scaffold
PubMed
Selfassembly
Record 3 MedChemExpress

Source

Oligopeptide P11-4 self-assembling peptide product page

Self-Assembly

Nanostructure formation
Beta-sheet amyloid-like scaffold
Low pH
Selfassembly; Nanostructure=Beta-sheet amyloid-like scaffold; Trigger=Low pH
Product/literature summary describes beta-sheet amyloid hydrogel appearance
Enamel regeneration oral care
biomimetic mineralization scaffold
MedChemExpress
Selfassembly
Evidence Records 3 records
Evidence 1 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Beta-sheet scaffold/hydrogel-like matrix Trigger=Low pH in caries lesion
Beta-sheet scaffold/hydrogel-like matrix

Source & Reference

NA
PubMed
10.1080/00016357.2020.1825799

Other

N-terminal acetylation C-terminal amidation
Early enamel caries enamel remineralization
biomimetic mineralization scaffold
Low pH in caries lesion
Systematic review AFM/SEM in erosion studies clinical studies
33026894
Self-assembling peptide P11-4 in remineralization of enamel caries - a systematic review of in-vitro studies
Commercial products include Curodont Repair / Curodont Repair Fluoride Plus.
Evidence 2 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Self-assembled enamel matrix-like scaffold Trigger=Low pH in caries lesion
Self-assembled enamel matrix-like scaffold

Source & Reference

NA
PubMed
10.1016/j.adaj.2023.03.014

Other

N-terminal acetylation C-terminal amidation
Initial caries lesion arrest and regression
biomimetic mineralization scaffold
Low pH in caries lesion
Clinical meta-analysis evidence
37245138
Systematic review and meta-analysis on the effect of self-assembling peptide P11-4 on arrest cavitation and progression of initial caries lesions
Duplicate retained because this is clinical-effectiveness evidence.
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Beta-sheet amyloid-like scaffold Trigger=Low pH
Beta-sheet amyloid-like scaffold

Source & Reference

NA
MedChemExpress

Other

N-terminal acetylation C-terminal amidation
Enamel regeneration oral care
biomimetic mineralization scaffold
Low pH
Product/literature summary describes beta-sheet amyloid hydrogel appearance
Oligopeptide P11-4 self-assembling peptide product page
Duplicate P11-4 row retained as low-detail product/source seed.
Additional Detail Fields 7 fields
Low pH in caries lesion Low pH
N-terminal acetylation C-terminal amidation
Commercial products include Curodont Repair / Curodont Repair Fluoride Plus. Duplicate retained because this is clinical-effectiveness evidence. Duplicate P11-4 row retained as low-detail product/source seed.
33026894 37245138
Self-assembling peptide P11-4 in remineralization of enamel caries - a systematic review of in-vitro studies Systematic review and meta-analysis on the effect of self-assembling peptide P11-4 on arrest cavitation and progression of initial caries lesions Oligopeptide P11-4 self-assembling peptide product page
Early enamel caries enamel remineralization Initial caries lesion arrest and regression Enamel regeneration oral care
biomimetic mineralization scaffold