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Peptide record

TPDB87395

RADA16-I Selfassembly modified_plain modified
16 amino acids
Basic Information
TPDB87395
RADA16-I
Selfassembly
Self-assembling and biomaterial peptides
PMC
modified_plain
Yes
A 16-aa modified selfassembly peptide sequence curated from PMC, without an available 3D structural model.
C-terminal: Amidation
Sequence
Ac-RADARADARADARADA-CONH2
Physicochemical Analysis
C83H138N36O31S2
EQGILKMFPSTWYV
A
2200.35
7.01
5
4
9
+0
7.53
-0.700
36.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
125
5.68
3
Residue Composition
number
9
A
4
R
1
N
4
D
2
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 9 R: 4 N: 1 D: 4 C: 2 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C83H138N36O31S2
2200.35
7.01
+0
7.53
-0.700
Self-Assembly Information 2 records
Record 1 PMC

Source

34178214
10.3389/fbioe.2021.679525
Clinical Use of the Self-Assembling Peptide RADA16: A Review of Current and Future Trends in Biomedicine

Self-Assembly

Nanostructure formation
Interwoven beta-sheet nanofiber hydrogel
Physiological pH and ionic biological fluids
Selfassembly; Nanostructure=Interwoven beta-sheet nanofiber hydrogel; Trigger=Physiological pH and ionic biological fluids
TEM/SEM beta-sheet CD rheology clinical/preclinical evidence
Hemostasis wound healing tissue regeneration
active peptide hydrogel scaffold
PMC
Selfassembly
Record 2 PMC

Source

23173072
10.1155/2012/853615
Molecular Mechanisms of RADA16-1 Peptide on Fast Stop Bleeding in Rat Models

Self-Assembly

Nanostructure formation
Nanofiber hydrogel scaffold
Contact with wound/blood physiological environment
Selfassembly; Nanostructure=Nanofiber hydrogel scaffold; Trigger=Contact with wound/blood physiological environment
Self-assembly described nanofiber scaffold animal bleeding models
Hemostasis
active peptide hydrogel scaffold
PMC
Selfassembly
Evidence Records 2 records
Evidence 1 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Interwoven beta-sheet nanofiber hydrogel Trigger=Physiological pH and ionic biological fluids
Interwoven beta-sheet nanofiber hydrogel

Source & Reference

NA
PMC
10.3389/fbioe.2021.679525

Other

N-terminal acetylation C-terminal amidation
Hemostasis wound healing tissue regeneration
active peptide hydrogel scaffold
Physiological pH and ionic biological fluids
TEM/SEM beta-sheet CD rheology clinical/preclinical evidence
34178214
Clinical Use of the Self-Assembling Peptide RADA16: A Review of Current and Future Trends in Biomedicine
Commercial formulation PuraStat also reported as RADA16-1.
Evidence 2 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanofiber hydrogel scaffold Trigger=Contact with wound/blood physiological environment
Nanofiber hydrogel scaffold

Source & Reference

NA
PMC
10.1155/2012/853615

Other

N-terminal acetylation C-terminal amidation
Hemostasis
active peptide hydrogel scaffold
Contact with wound/blood physiological environment
Self-assembly described nanofiber scaffold animal bleeding models
23173072
Molecular Mechanisms of RADA16-1 Peptide on Fast Stop Bleeding in Rat Models
Duplicate sequence retained because therapeutic evidence is hemostasis-focused.
Additional Detail Fields 7 fields
Physiological pH and ionic biological fluids Contact with wound/blood physiological environment
N-terminal acetylation C-terminal amidation
Commercial formulation PuraStat also reported as RADA16-1. Duplicate sequence retained because therapeutic evidence is hemostasis-focused.
34178214 23173072
Clinical Use of the Self-Assembling Peptide RADA16: A Review of Current and Future Trends in Biomedicine Molecular Mechanisms of RADA16-1 Peptide on Fast Stop Bleeding in Rat Models
Hemostasis wound healing tissue regeneration
active peptide hydrogel scaffold