TPDB

TPDB ID TPDB77639

Peptide_Name

LinNMe

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 30-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

YaGF-(Nω-methylguanidino)A-NH2

FASTA

>TPDB77639|Blood-Brain Barrier|length=30
YaGF-(Nω-methylguanidino)A-NH2

Formula C104H149N29O33S1

Absent Amino Acids RCQKPSWV

Common Amino Acids N

Mass 2365.56

PI 5.05

Basic Residues 2

Acidic Residues 2

Hydrophobic Residues 10

Net Charge -2

Boman Index 2.08

Hydrophobicity -0.287

Aliphatic Index 49.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 2980

Absorbance 280nm 125.97

Polar Residues 7

number

3

A

0

R

4

N

1

D

0

C

1

E

0

Q

2

G

2

H

2

I

1

L

0

K

1

M

1

F

0

P

0

S

1

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 3 R: 0 N: 4 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 2 I: 2 L: 1 K: 0 M: 1 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 0

Length

30

Formula

C104H149N29O33S1

Mass

2365.56

PI

5.05

Net Charge

-2

Boman Index

2.08

Hydrophobicity

-0.287

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-(D)Ala-Gly-Phe-(NÏ‰-methylguanidino)Ala-NH2

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.02 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 14.16%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 85.84%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00017 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.02347 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin synthetic,milkweed bug

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous