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Peptide record

TPDB77638

[(D)Ala2, (N-Me)Phe4 Blood-Brain Barrier modified_plain modified
16 amino acids
Basic Information
TPDB77638
[(D)Ala2, (N-Me)Phe4
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 16-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Modified, details unspecified
Sequence
YaG-(N-Me)F-G-OH
Physicochemical Analysis
C45H60N12O14S1
RDCQILKPSTWV
G
1025.10
5.13
1
1
4
-1
0.95
-0.363
6.25
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
145.35
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
1
E
0
Q
2
G
1
H
0
I
0
L
0
K
1
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
16
C45H60N12O14S1
1025.10
5.13
-1
0.95
-0.363
Linear
Similarity
Tyr-(D)Ala-Gly-(N-Me)Phe-Gly-OH
O=C(NCCO)C(N(C(=O)CNC(=O)C(NC(=O)C(N)Cc1ccc(O)cc1)C)C)Cc2ccccc2
Evidence Records 8 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
10.66 min

Assay & Model

Efflux study ICU
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Permeability
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.065 min-1

Assay & Model

Efflux study ICU
Origin/Source
Brain elemination rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
7.30%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
92.70%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
200 min

Assay & Model

HPLC
Origin/Source
half life, serum

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
900 min

Assay & Model

HPLC
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 7 Activity

Activity

Blood-Brain Barrier
0.0004 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
non saturable
Direct iodination
Evidence 8 Activity

Activity

Blood-Brain Barrier
0.03453 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
non saturable
Direct iodination
Additional Detail Fields 1 fields
Intravenous