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Peptide record

TPDB77637

p-[Cl-Phe4’4’] Bipha Blood-Brain Barrier modified_plain modified
25 amino acids
Basic Information
TPDB77637
p-[Cl-Phe4’4’] Bipha
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 25-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Modified, details unspecified
Sequence
YaG-(Cl)F-NH-NH-(Cl)F-GaY
Physicochemical Analysis
C84H112N22O21S2
RDEQIKMPSTWV
ANCGHLFY
1830.07
7.16
2
0
8
+0
-3.30
0.200
39.20
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
3105
169.67
6
Residue Composition
number
2
A
0
R
2
N
0
D
2
C
0
E
0
Q
2
G
2
H
0
I
2
L
0
K
0
M
2
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 2 I: 0 L: 2 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
25
C84H112N22O21S2
1830.07
7.16
+0
-3.30
0.200
Linear
Similarity
[Tyr-(D)Ala-Gly-(Cl)Phe-NH]2
Clc1ccc(cc1)C[C@H](C(=O)NNC(=O)[C@H](NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C)Cc3ccc(Cl)cc3)NC(=O)CNC(=O)[C@H](NC(=O)[C@H](N)Cc4ccc(O)cc4)C
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
-0.11

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

human
Direct iodination