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Peptide record

TPDB77631

TAPP Blood-Brain Barrier modified_plain modified

8 amino acids

TPDB ID TPDB77631

Peptide_Name

TAPP

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 8-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

YaFF-NH2

FASTA

>TPDB77631|Blood-Brain Barrier|length=8
YaFF-NH2

Formula C40H47N9O9

Absent Amino Acids RDCEQGILKMPSTWV

Common Amino Acids F

Mass 797.87

PI 7.77

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +0

Boman Index -1.99

Hydrophobicity -0.075

Aliphatic Index 12.50

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 186.75

Polar Residues 2

number

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

Formula

C40H47N9O9

Mass

797.87

7.77

Net Charge

Boman Index

-1.99

Hydrophobicity

-0.075

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-(D)Ala-Phe-Phe-NH2

SMILES

O=C(N)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccc(O)cc1)C)Cc2ccccc2)Cc3ccccc3

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 2.82 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.25 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 18.52%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 81.48%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 200 min

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response half life, serum

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 900 min

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00112 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

Evidence 8 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.03176 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin bovine

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous