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Peptide record

TPDB77625

PEG-D-Penicillamine- Blood-Brain Barrier modified_plain modified
17 amino acids
Basic Information
TPDB77625
PEG-D-Penicillamine-
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 17-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Chemical: Pen2-pen5
Sequence
mPEG-Y-pen-GF-pen
Physicochemical Analysis
C65H89N15O23S1
ARDCQHILKSTWV
EP
1480.57
3.03
0
3
3
-3
5.97
-1.159
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
100.64
3
Residue Composition
number
0
A
0
R
2
N
0
D
0
C
3
E
0
Q
2
G
0
H
0
I
0
L
0
K
1
M
1
F
3
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 0 E: 3 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 1 F: 1 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
17
C65H89N15O23S1
1480.57
3.03
-3
5.97
-1.159
Pen2-pen5
Linear
Similarity
mPEG-Tyr-(D)Pen-Gly-Phe-D(Pen)
Evidence Records 4 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
-2.05

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
3.41%

Assay & Model

Origin/Source
in vitro influx rate

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
In situ perfusion (single time)
Saturable
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
1.37%

Assay & Model

Capillary deplition in situ b p
Origin/Source
Gas constant pellet

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Saturable
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
2.70%

Assay & Model

Capillary deplition in situ b p
Origin/Source
Gas constant supernatant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Saturable
Direct iodination
Additional Detail Fields 1 fields
In situ perfusion (single time)