Back to search

Peptide record

TPDB77623

CTOP Blood-Brain Barrier modified_plain modified
16 amino acids
Basic Information
TPDB77623
CTOP
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 16-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Amidation Chemical: Cys2-Pen7
Sequence
fCYwOrnTPenT-NH2
Physicochemical Analysis
C74H100N22O22S1
ADQGILKMSV
N
1681.80
7.15
2
1
3
+0
1.62
-1.350
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
6990
415.63
7
Residue Composition
number
0
A
1
R
3
N
0
D
1
C
1
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
1
F
1
P
0
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 3 D: 0 C: 1 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
16
C74H100N22O22S1
1681.80
7.15
+0
1.62
-1.350
Cys2-Pen7
Linear
Similarity
(D)Phe-Cys-Tyr-(D)Trp-Orn-Thr-Pen-Thr-NH2
O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2(C)C)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCN)C(O)C)C(O)C
Evidence Records 4 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
200 min

Assay & Model

HPLC
Origin/Source
half life, serum

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
900 min

Assay & Model

HPLC
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.00024 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
non saturable
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.01894 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
non saturable
Direct iodination
Additional Detail Fields 1 fields
Intravenous