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Peptide record

TPDB77622

Vapreotide Blood-Brain Barrier modified_plain modified

12 amino acids

TPDB ID TPDB77622

Peptide_Name

Vapreotide

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 12-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation Chemical: Cys2-Cys7

Sequence

fCYwKVCW-NH2

FASTA

>TPDB77622|Blood-Brain Barrier|length=12
fCYwKVCW-NH2

Formula C67H84N16O13S2

Absent Amino Acids ARDEQGILMPST

Common Amino Acids CW

Mass 1385.62

PI 8.28

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +1

Boman Index -3.81

Hydrophobicity -0.142

Aliphatic Index 24.17

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 12615

Absorbance 280nm 910.42

Polar Residues 4

number

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 1 V: 1

Length

Formula

C67H84N16O13S2

Mass

1385.62

8.28

Net Charge

Boman Index

-3.81

Hydrophobicity

-0.142

Chemical_Modification

Cys2-Cys7

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Trp-NH2

SMILES

O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)Cc7c6ccccc6nc7

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0000923 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0137 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial distribution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 1.05 min

Assay & Model

Animal Model Origin/Source

Response half life, serum

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 24 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.029 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Saturable

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 20.3 µL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Permeability surface area cofficient

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery in situ brain perfusion

Transport Type non saturable

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 41.6 %/g

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response % injected dose

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 8 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 36.9 %/g

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response % injected dose

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous in situ brain perfusion