TPDB

TPDB ID TPDB77621

Peptide_Name

RC-121

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 12-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation Chemical: Cys2-Cys7

Sequence

fCYwKVCT-NH2

FASTA

>TPDB77621|Blood-Brain Barrier|length=12
fCYwKVCT-NH2

Formula C60H81N15O14S2

Absent Amino Acids ARDEQGILMPS

Common Amino Acids C

Mass 1300.52

PI 8.28

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +1

Boman Index -1.82

Hydrophobicity -0.125

Aliphatic Index 24.17

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 7115

Absorbance 280nm 547.09

Polar Residues 5

number

0

A

0

R

1

N

0

D

2

C

0

E

0

Q

0

G

1

H

0

I

0

L

1

K

0

M

1

F

0

P

0

S

1

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 1

Length

12

Formula

C60H81N15O14S2

Mass

1300.52

PI

8.28

Net Charge

+1

Boman Index

-1.82

Hydrophobicity

-0.125

Chemical_Modification

Cys2-Cys7

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

(D)Phe-Cys-Tyr-(D)Trp-Lys-Val-Cys-Thr-NH2

SMILES

O=C(N)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CSSC2)Cc3ccc(O)cc3)Cc5c4ccccc4nc5)CCCCN)C(C)C)C(O)C

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 14.4 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse,rat

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.05 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse,rat

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0000401 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse,rat

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0136 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse,rat

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 4.6 min

Assay & Model

Animal Model Origin/Source

Response half life, serum

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin mouse,rat

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous