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Peptide record

TPDB77605

TAPA Blood-Brain Barrier modified_plain modified
6 amino acids
Basic Information
TPDB77605
TAPA
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 6-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Modified, details unspecified
Sequence
YrF-βA
Physicochemical Analysis
C27H37N7O6
NDCEQGHILKMPSTWV
ARFY
555.63
9.88
1
0
3
+1
-1.43
-0.200
16.67
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
268.16
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
6
C27H37N7O6
555.63
9.88
+1
-1.43
-0.200
Linear
Similarity
Tyr-(D)Arg-Phe-βAla
O=C(O)CCNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)CCCNC(=[N@H])N)Cc2ccccc2
Evidence Records 2 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.000265 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional influx rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Saturable
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.00869 ml/g

Assay & Model

Origin/Source
Initial disrobution volume

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Intravenous
Saturable
Direct iodination
Additional Detail Fields 1 fields
Intravenous