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Peptide record

TPDB77604

LSZ 1025 Blood-Brain Barrier modified_plain modified
11 amino acids
Basic Information
TPDB77604
LSZ 1025
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 11-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Amidation C-terminal: Chemical modification Chemical: (D)Cys2-(D)Cys5 N-terminal: C-terminal modification
Sequence
YcGFcSG-NH2
Physicochemical Analysis
C41H54N12O13S2
ARDEQILKMPTWV
CG
987.07
7.00
1
0
2
-0
-1.02
-0.164
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1615
163.62
5
Residue Composition
number
0
A
0
R
1
N
0
D
2
C
0
E
0
Q
2
G
1
H
0
I
0
L
0
K
0
M
1
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C41H54N12O13S2
987.07
7.00
-0
-1.02
-0.164
Chemical modification
(D)Cys2-(D)Cys5
Linear
C-terminal modification
Similarity
Tyr-(D)Cys-Gly-Phe-(D)Cys-Ser-Gly-NH2
O=C(N)CNC(=O)[C@H](NC(=O)[C@@H]2NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)CSSC2)Cc3ccccc3)CO
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.00079 ml/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant,initial

Source & Reference

NA
B3Pdb

Other

rat,porcine
in situ brain perfusion
Permeability
Direct iodination
Additional Detail Fields 1 fields
in situ brain perfusion