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Peptide record

TPDB77597

Biphalin Blood-Brain Barrier modified_plain modified
15 amino acids
Basic Information
TPDB77597
Biphalin
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 15-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Modified, details unspecified
Sequence
YaGF-NH-NH-FGaY
Physicochemical Analysis
C66H80N18O17
RDCEQILKMPSTWV
ANGHFY
1397.47
7.86
2
0
6
+0
-1.70
-0.507
13.33
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
213.24
4
Residue Composition
number
2
A
0
R
2
N
0
D
0
C
0
E
0
Q
2
G
2
H
0
I
0
L
0
K
0
M
2
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 2 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
15
C66H80N18O17
1397.47
7.86
+0
-1.70
-0.507
Linear
Similarity
Tyr-(D)Ala-Gly-Phe-NH-NH-Phe-Gly-(D)Ala-Tyr
O=C(N[C@@H](C(=O)NCC(=O)N[C@H](C(=O)NNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C)Cc2ccccc2)Cc3ccccc3)C)[C@@H](N)Cc4ccc(O)cc4
Evidence Records 9 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.001 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant

Source & Reference

NA
B3Pdb

Other

cat
in situ brain perfusion
Permeability
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.0097 ml/g

Assay & Model

Origin/Source
Initial distribution vaolume

Source & Reference

NA
B3Pdb

Other

cat
in situ brain perfusion
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.00192 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (parenchyma/serum)

Source & Reference

NA
B3Pdb

Other

cat
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.00091 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (capillary/serum)

Source & Reference

NA
B3Pdb

Other

cat
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
68%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

cat
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
32%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

cat
Direct iodination
Evidence 7 Activity

Activity

Blood-Brain Barrier
118 min

Assay & Model

HPLC
Origin/Source
half life, serum

Source & Reference

NA
B3Pdb

Other

cat
Direct iodination
Evidence 8 Activity

Activity

Blood-Brain Barrier
312 min

Assay & Model

HPLC
Origin/Source
half life, serum

Source & Reference

NA
B3Pdb

Other

cat
Direct iodination
Evidence 9 Activity

Activity

Blood-Brain Barrier
0.45

Assay & Model

Shake Flask
Origin/Source
Log D

Source & Reference

NA
B3Pdb

Other

cat
Direct iodination
Additional Detail Fields 1 fields
in situ brain perfusion