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Peptide record

TPDB77592

Tyr-Trp-Melanocyt-st Blood-Brain Barrier modified_plain modified
8 amino acids
Basic Information
TPDB77592
Tyr-Trp-Melanocyt-st
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 8-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Amidation
Sequence
YPWG-NH2
Physicochemical Analysis
C37H44N10O9
ARDCEQILKMFSTV
NGHPWY
772.82
7.77
1
0
2
+0
-0.95
-1.363
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
6990
904.48
2
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
8
C37H44N10O9
772.82
7.77
+0
-0.95
-1.363
Linear
Similarity
Tyr-Pro-Trp-Gly-NH2
O=C(NC(C(=O)NCC(=O)N)Cc2c1ccccc1nc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4
Evidence Records 2 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.038 %/g

Assay & Model

HPLC
Origin/Source
% injected dose

Source & Reference

NA
B3Pdb
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.0000633333 cm/s

Assay & Model

BMEC
Origin/Source
Permeability coefficient

Source & Reference

NA
B3Pdb

Other

Permeability