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Peptide record

TPDB77591

Endomorphin-1 Blood-Brain Barrier modified_plain modified

8 amino acids

TPDB ID TPDB77591

Peptide_Name

Endomorphin-1

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 8-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

YPWF-NH2

FASTA

>TPDB77591|Blood-Brain Barrier|length=8
YPWF-NH2

Formula C44H50N10O9

Absent Amino Acids ARDCEQGILKMSTV

Common Amino Acids NHFPWY

Mass 862.94

PI 7.77

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +0

Boman Index -2.09

Hydrophobicity -0.963

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 810.02

Polar Residues 2

number

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 1 V: 0

Length

Formula

C44H50N10O9

Mass

862.94

7.77

Net Charge

Boman Index

-2.09

Hydrophobicity

-0.963

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-Pro-Trp-Phe-NH2

SMILES

O=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc3c2ccccc2nc3)C5N(C(=O)C(N)Cc4ccc(O)cc4)CCC5

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00106 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.04384 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial distribution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 7.75 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Saturable

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.089 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Saturable

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.047 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Saturable

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 14.7 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Saturable

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 88.69%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Label Direct iodination

Evidence 8 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 11.31%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Label Direct iodination

Evidence 9 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 7 min

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response half life, serum

Source & Reference

Database Source NA

Source B3Pdb

Other

Label Direct iodination

Evidence 10 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 205 min

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous