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Peptide record

TPDB77584

Endom Endomorphin-2 Blood-Brain Barrier modified_plain modified

8 amino acids

TPDB ID TPDB77584

Peptide_Name

Endom Endomorphin-2

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 8-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

YPFF-NH2

FASTA

>TPDB77584|Blood-Brain Barrier|length=8
YPFF-NH2

Formula C42H49N9O9

Absent Amino Acids ARDCEQGILKMSTWV

Common Amino Acids F

Mass 823.91

PI 7.77

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +0

Boman Index -1.37

Hydrophobicity -0.500

Aliphatic Index 0.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 180.85

Polar Residues 2

number

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

Formula

C42H49N9O9

Mass

823.91

7.77

Net Charge

Boman Index

-1.37

Hydrophobicity

-0.500

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-Pro-Phe-Phe-NH2

SMILES

O=C(NC(C(=O)NC(C(=O)N)Cc1ccccc1)Cc2ccccc2)C4N(C(=O)C(N)Cc3ccc(O)cc3)CCC4

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00114 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.05224 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial distribution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

In Vivo Mode of Delivery Intravenous

Transport Type non saturable

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 10.18 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Saturable

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.032 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Saturable

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 21.97 min

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Saturable

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.068 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Saturable

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 96.36%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Label Direct iodination

Evidence 8 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 3.64%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Label Direct iodination

Evidence 9 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 88 min

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Label Direct iodination

Evidence 10 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 3.8 min

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response half life, brain

Source & Reference

Database Source NA

Source B3Pdb

Other

Label H3/C14

Evidence 11 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 4 min

Assay & Model

In Vitro Method HPLC

Animal Model Origin/Source

Response half life, serum

Source & Reference

Database Source NA

Source B3Pdb

Other

Label Direct iodination

Evidence 12 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.457

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log P

Source & Reference

Database Source NA

Source B3Pdb

Other

Label H3/C14

Evidence 13 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 1.57

Assay & Model

In Vitro Method Shake Flask

Animal Model Origin/Source

Response Log D

Source & Reference

Database Source NA

Source B3Pdb

Other

Label Direct iodination

Evidence 14 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00005317 cm/s

Assay & Model

In Vitro Method BMEC

Animal Model Origin/Source

Response Permeability coefficient

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Permeability

Label Direct iodination

Evidence 15 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 4.02 ml/g

Assay & Model

In Vitro Method BMEC

Animal Model Origin/Source

Response Initial distribution Initial distribution Initial distribution Initial distribution Initial distribu

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Permeability

Label Direct iodination

Evidence 16 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.0347 mL/(g x min)

Assay & Model

In Vitro Method BMEC

Animal Model Origin/Source

Response Unidirectonal influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type Permeability

Label Direct iodination

Evidence 17 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00000784 cm/s

Assay & Model

In Vitro Method BMEC

Animal Model Origin/Source

Response Permeability coefficientendoth

Source & Reference

Database Source NA

Source B3Pdb

Other

Transport Type non saturable

Label H3/C14

In_Vivo_Mode_of_Delivery

Intravenous