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Peptide record

TPDB77575

p-[I-Phe4]DPLPE-Phe Blood-Brain Barrier modified_plain modified
18 amino acids
Basic Information
TPDB77575
p-[I-Phe4]DPLPE-Phe
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 18-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Chemical: Pen2-pen5
Sequence
Y-pen-G-pI-F-Pen-F
Physicochemical Analysis
C68H90N14O20
ARDCQHLKMSTWV
P
1423.54
3.13
0
2
4
-2
2.73
-0.578
21.67
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
104.67
3
Residue Composition
number
0
A
0
R
2
N
0
D
0
C
2
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
2
F
3
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 2 P: 3 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
18
C68H90N14O20
1423.54
3.13
-2
2.73
-0.578
Pen2-pen5
Linear
Similarity
Tyr-(D)Pen-Gly-pI-Phe-Pen-Phe
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.00001667 cm/s

Assay & Model

BMEC
Origin/Source
Permeability coefficient

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Permeability