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Peptide record

TPDB77571

VDE243 VDE380 Blood-Brain Barrier modified_plain modified
9 amino acids
Basic Information
TPDB77571
VDE243 VDE380
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 9-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Modified, details unspecified
Sequence
Y-glc-GFL
Physicochemical Analysis
C37H53N7O9S1
ARNDEQHIKMPSTWV
GL
771.93
5.32
0
0
4
-0
-3.41
1.200
86.67
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
193.02
2
Residue Composition
number
0
A
0
R
0
N
0
D
1
C
0
E
0
Q
2
G
0
H
0
I
2
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
9
C37H53N7O9S1
771.93
5.32
-0
-3.41
1.200
Linear
Similarity
Tyr-glucose-Gly-Phe-Leu
O=C(O)[C@@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@]2(NC(=O)[C@@H](N)Cc1ccc(O)cc1)C[C@@H](O)[C@H](O)C(O)C2)Cc3ccccc3)CC(C)C O=C(O)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@]2(NC(=O)[C@H](N)Cc1ccc(O)cc1)C[C@H](O)[C@@H](O)C(O)C2)Cc3ccccc3)CC(C)C
Evidence Records 2 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
76.29%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
200 min

Assay & Model

HPLC
Origin/Source
half life, serum

Source & Reference

NA
B3Pdb

Other

frog
Direct iodination