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Peptide record

TPDB77570

CycNMe CycS Blood-Brain Barrier modified_plain modified

39 amino acids

TPDB ID TPDB77570

Peptide_Name

CycNMe CycS

Activity

Blood-Brain Barrier

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 39-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

Y-cyclo(aGF-(Nω-methylguanidino)A-)-NH2

FASTA

>TPDB77570|Blood-Brain Barrier|length=39
Y-cyclo(aGF-(Nω-methylguanidino)A-)-NH2

Formula C125H179N33O38S3

Absent Amino Acids RQKPSWV

Common Amino Acids N

Mass 2848.17

PI 5.05

Basic Residues 2

Acidic Residues 2

Hydrophobic Residues 12

Net Charge -2

Boman Index 0.10

Hydrophobicity -0.028

Aliphatic Index 47.69

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 4595

Absorbance 280nm 161.33

Polar Residues 10

number

Amino Acid Distribution

A: 3 R: 0 N: 4 D: 1 C: 2 E: 1 Q: 0 G: 2 H: 2 I: 2 L: 2 K: 0 M: 1 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 3 V: 0

Length

Formula

C125H179N33O38S3

Mass

2848.17

5.05

Net Charge

-2

Boman Index

0.10

Hydrophobicity

-0.028

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Tyr-cyclo((D)Ala-Gly-Phe-NÏ‰-methylguanidinoAla-)-NH2

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.1 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 2 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 21.44%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 3 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 78.56%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 4 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00011 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 5 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.02336 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 6 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result -0.06 min-1

Assay & Model

In Vitro Method Efflux study ICU

Animal Model Origin/Source

Response Brain elemination rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Transport Type Permeability

Label Direct iodination

Evidence 7 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 28.74%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % capillary

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 8 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 71.26%

Assay & Model

In Vitro Method Capillary depletion

Animal Model Origin/Source

Response % parenchyma

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

Label Direct iodination

Evidence 9 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.00031 mL/(g x min)

Assay & Model

Animal Model Origin/Source

Response Unidirectional influx rate constant

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

Evidence 10 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Activity Result 0.01812 ml/g

Assay & Model

Animal Model Origin/Source

Response Initial disrobution volume

Source & Reference

Database Source NA

Source B3Pdb

Other

Source Origin Chemically synthesized

In Vivo Mode of Delivery Intravenous

Transport Type Permeability

Label Direct iodination

In_Vivo_Mode_of_Delivery

Intravenous