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Peptide record

TPDB77566

D-Penicillamine-D-Pe Blood-Brain Barrier modified_plain modified
12 amino acids
Basic Information
TPDB77566
D-Penicillamine-D-Pe
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 12-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Chemical: (D)Pen2-(D)Pen5
Sequence
Y-Pen-GF-Pen
Physicochemical Analysis
C48H63N11O17
ARDCQHILKMSTWV
NEP
1066.09
3.13
0
2
2
-2
3.72
-1.342
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
139.76
3
Residue Composition
number
0
A
0
R
2
N
0
D
0
C
2
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C48H63N11O17
1066.09
3.13
-2
3.72
-1.342
(D)Pen2-(D)Pen5
Linear
Similarity
Tyr-(D)Pen-Gly-Phe-(D)Pen
O=C(O)[C@@H]2NC(=O)[C@H](NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(SSC2(C)C)(C)C)Cc3ccccc3
Evidence Records 8 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.0022 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant

Source & Reference

NA
B3Pdb

Other

human
in situ brain perfusion
Permeability
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.0143 ml/g

Assay & Model

Origin/Source
Initial distribution vaolume

Source & Reference

NA
B3Pdb

Other

human
in situ brain perfusion
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.00481 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (parenchyma/serum)

Source & Reference

NA
B3Pdb

Other

human
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
0.00066 ml/g

Assay & Model

Capillary depletion
Origin/Source
Capillary depletion (capillary/serum)

Source & Reference

NA
B3Pdb

Other

human
Direct iodination
Evidence 5 Activity

Activity

Blood-Brain Barrier
88%

Assay & Model

Capillary depletion
Origin/Source
% parenchyma

Source & Reference

NA
B3Pdb

Other

human
Direct iodination
Evidence 6 Activity

Activity

Blood-Brain Barrier
12%

Assay & Model

Capillary depletion
Origin/Source
% capillary

Source & Reference

NA
B3Pdb

Other

human
Direct iodination
Evidence 7 Activity

Activity

Blood-Brain Barrier
500 min

Assay & Model

HPLC
Origin/Source
half life, serum

Source & Reference

NA
B3Pdb

Other

human
Direct iodination
Evidence 8 Activity

Activity

Blood-Brain Barrier
-0.602

Assay & Model

Shake Flask
Origin/Source
Log D

Source & Reference

NA
B3Pdb

Other

human
Direct iodination
Additional Detail Fields 1 fields
in situ brain perfusion