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Peptide record

TPDB77565

[p-Cl-Phe4]-[(D)Pen2 Blood-Brain Barrier modified_plain modified
23 amino acids
Basic Information
TPDB77565
[p-Cl-Phe4]-[(D)Pen2
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 23-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
Chemical: (D)Pen2-(D)Pen5
Sequence
Y-(D)Pen-G-(Cl)F-(D)Pen
Physicochemical Analysis
C65H89N15O25S1
ARQHIKMSTWV
NDEP
1512.57
2.83
0
4
3
-4
5.38
-0.730
16.96
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
98.51
4
Residue Composition
number
0
A
0
R
2
N
2
D
1
C
2
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 2 C: 1 E: 2 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
23
C65H89N15O25S1
1512.57
2.83
-4
5.38
-0.730
(D)Pen2-(D)Pen5
Linear
Similarity
Tyr-(D)Pen-Gly-(Cl)Phe-(D)Pen
O=C(O)[C@H]2NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(SSC2(C)C)(C)C)Cc3ccc(Cl)cc3
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.000137933 cm/s

Assay & Model

BMEC
Origin/Source
Permeability coefficient

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Permeability