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Peptide record

TPDB77563

[(1S,2R)-Achc]²-Endo Blood-Brain Barrier modified_plain modified
20 amino acids
Basic Information
TPDB77563
[(1S,2R)-Achc]²-Endo
Blood-Brain Barrier
Delivery and barrier-penetrating peptides
Peptipedia
modified_plain
Yes
A 20-aa modified blood-brain barrier peptide sequence curated from Peptipedia, without an available 3D structural model.
C-terminal: Amidation
Sequence
Y-(1S,2R)Achc-FF-NH2
Physicochemical Analysis
C61H81N19O15S2
DEQGILKMPTWV
CHF
1384.55
8.29
3
0
4
+1
-0.57
-0.205
5.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1615
116.64
5
Residue Composition
number
1
A
1
R
1
N
0
D
2
C
0
E
0
Q
0
G
2
H
0
I
0
L
0
K
0
M
2
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 2 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
20
C61H81N19O15S2
1384.55
8.29
+1
-0.57
-0.205
Linear
Similarity
Tyr-(1S,2R)Achc-Phe-Phe-NH2
Evidence Records 3 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
270 min

Assay & Model

HPLC
Origin/Source
half life, brain

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
H3/C14
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.925

Assay & Model

Shake Flask
Origin/Source
Log P

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
H3/C14
Evidence 3 Activity

Activity

Blood-Brain Barrier
0.00001513 cm/s

Assay & Model

BMEC
Origin/Source
Permeability coefficientendoth

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
non saturable
H3/C14